Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development
Identifieur interne : 000089 ( Main/Exploration ); précédent : 000088; suivant : 000090Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development
Auteurs : Jiantao Zhang [États-Unis] ; Yanmei Hu [États-Unis] ; Rami Musharrafieh [États-Unis] ; Hang Yin [États-Unis] ; Jun Wang [États-Unis]Source :
- Current medicinal chemistry [ 0929-8673 ] ; 2019.
Abstract
Influenza viruses are severe human pathogens that pose persistent threat to public health. Each year more people die of influenza virus infection than that of breast cancer. Due to the limited efficacy associated with current influenza vaccines, as well as emerging drug resistance from small molecule antiviral drugs, there is a clear need to develop new antivirals with novel mechanisms of action. The influenza virus polymerase complex has become a promising target for the development of the next-generation of antivirals for several reasons. Firstly, the influenza virus polymerase, which forms a heterotrimeric complex that consists of PA, PB1, and PB2 subunits, is highly conserved. Secondly, both individual polymerase subunit (PA, PB1, and PB2) and inter-subunit interactions (PA-PB1, PB1-PB2) represent promising drug targets. Lastly, growing insight into the structure and function of the polymerase complex has spearheaded the structure-guided design of new polymerase inhibitors. In this review, we highlight recent progress in drug discovery and assay development targeting the influenza virus polymerase complex and discuss their therapeutic potentials.
Url:
DOI: 10.2174/0929867325666180706112940
PubMed: 29984646
PubMed Central: 6426683
Affiliations:
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xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721</wicri:regionArea><wicri:noRegion>Arizona 85721</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Yanmei" sort="Hu, Yanmei" uniqKey="Hu Y" first="Yanmei" last="Hu">Yanmei Hu</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721</wicri:regionArea><wicri:noRegion>Arizona 85721</wicri:noRegion></affiliation></author><author><name sortKey="Musharrafieh, Rami" sort="Musharrafieh, Rami" uniqKey="Musharrafieh R" first="Rami" last="Musharrafieh">Rami Musharrafieh</name><affiliation wicri:level="1"><nlm:aff 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when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Influenza viruses are severe human pathogens that pose persistent threat to public health. Each year more people die of influenza virus infection than that of breast cancer. Due to the limited efficacy associated with current influenza vaccines, as well as emerging drug resistance from small molecule antiviral drugs, there is a clear need to develop new antivirals with novel mechanisms of action. The influenza virus polymerase complex has become a promising target for the development of the next-generation of antivirals for several reasons. Firstly, the influenza virus polymerase, which forms a heterotrimeric complex that consists of PA, PB1, and PB2 subunits, is highly conserved. Secondly, both individual polymerase subunit (PA, PB1, and PB2) and inter-subunit interactions (PA-PB1, PB1-PB2) represent promising drug targets. Lastly, growing insight into the structure and function of the polymerase complex has spearheaded the structure-guided design of new polymerase inhibitors. In this review, we highlight recent progress in drug discovery and assay development targeting the influenza virus polymerase complex and discuss their therapeutic potentials.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Zhang, Jiantao" sort="Zhang, Jiantao" uniqKey="Zhang J" first="Jiantao" last="Zhang">Jiantao Zhang</name></noRegion><name sortKey="Hu, Yanmei" sort="Hu, Yanmei" uniqKey="Hu Y" first="Yanmei" last="Hu">Yanmei Hu</name><name sortKey="Musharrafieh, Rami" sort="Musharrafieh, Rami" uniqKey="Musharrafieh R" first="Rami" last="Musharrafieh">Rami Musharrafieh</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><name sortKey="Yin, Hang" sort="Yin, Hang" uniqKey="Yin H" first="Hang" last="Yin">Hang Yin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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